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Leonidas Stefanis, Professor of Neurology and Neurobiology, Medical School of Athens, National & Kapodistrian University of Athens

Spiros Efthimiopoulos, Professor of Neurobiology, Department of Biology, Division of Animal & Human Physiology, National & Kapodistrian University of Athens

Teaching hours and weekly schedule

This is a 2nd semester, 3,5 weeks elective course that corresponds to 6 ECTs and 53 total hours of lectures and student presentations.


This is an intensive three and a half-week course focused on the Genetics, the general processes that operate in several different neurological disorders, the pathology of neurological disorders, their molecular basis, as well as experimental therapeutics. The goal of this intensive course is that students become well versed with the genetic and molecular basis of the disorders of the nervous system.

Course Overview

The course covers general principles that apply to several disorders of the nervous system as well as the description and the pathology and the molecular basis of individual diseases.

General principles include:

•             Protein misfolding and aggregation,

•             protein degradation

•             Inflammation

•             Neurotoxic and neurotrophic pathways

Examples of the diseases of the nervous system that will be covered include:

•             Alzheimer's disease

•             Parkinson's disease

•             Motor Neuron Disease

•             Schizophrenia

•             Depression

•             Triple repeat disorders

•             Epilepsy

•             Addiction

•             Nervous System Cancers

•             Brain and Spinal Cord injury

Skills & Learning Outcomes

Upon successful completion of this course, students will be able to:

1.            Understand the common mechanisms involved in various diseases of the nervous system

2.            Understand the genetics of neurological diseases

3.            Understand and describe the molecular pathways that operate in specific disorders of the nervous system

Titles of lectures and names of the lecturers

Neurobiological Basis of Diseases of the Nervous System Lecturers
Co-ordinators: Leonidas Stefanis, Spiros Efthimiopoulos
Neurodegenerative diseases as proteinopathies Kostas Vekrellis
Molecular and Cellular Biology of Parkinsons's Disease and related synucleinopathies Leonidas Stefanis
Molecular and Cellular Biology of Alzheimer's Disease Spiros Efthimiopoulos
Neurodevelopmental and neuronal migration disorders of the human brain Christina Kyrousi
Protein degradation in neurodegenerative diseases Maria Xilouri
Mechanisms of Addiction Stella Vlahou, Alexia Polissidis
Brain and Spinal Cord injury Florentia Papastefanaki
Motor Neuron Disease Laskaro Zagoreou
Neuroprotection in neurodegenerative diseases Dimitris Vassilatis
Molecular Basis of taupathies Katerina Papanikolopoulou
Biomarkers of neurodegenerative diseases Elisavet Kapaki
Cognitive Functions and behavior in dementias Sokratis Papageorgiou
Life Style and neurodegeneration Nikos Scarmeas
Epilepsy Anastasios Bonakis
Triple repeat disorders George Koutsis
Molecular and Genetic Basis of Schizophrenia Alex Hatzimanolis
Cognitive deficits in Schizophrenia and depression Nikos Smyrnis
Biology of Depression Christina Dalla, Nikolaos Kokras
Nervous System Cancers Mimika Mangoura