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Technical courses II: Methodological approaches in Neuroscience , Experimental animal models in Neuroscience

Co-Coordinators

Efthimios M.C. Skoulakis, Researcher A’

Neurobiology Division BSRC Alexander Fleming

Spyros Georgopoulos, Researcher B’

Biomedical Research Foundation of the Academy of Athens

Description

This is an intensive lecture course focused on popular experimental models used on Neurobiological research. The course aims to explore the main attributes of various experimental systems that makes them suitable to or preferable to address particular types of questions and the depth and generality of answers thus obtained. 

Course Overview

Interdisciplinary approach to functional neurobiology and its tools including transgenics, RNA interference, particular usefulness and contributions of selected model systems. Total 33 class hours

Each system will be examined/presented along the following axes:

  1. Usefulness of the model/ contributions
  2. Manipulations to make transfectants/transgenics
  3. Models/ examples of Neurochemistry
  4. Models/ examples of Cognitive and Neurodegenerative diseases.

Models will include

  1. Neuronal cells in culture
  2. Caenorhabditis elegans
  3. Drosophila melanogaster
  4. Mouse/Rat

Detailed syllabus

1. Cultured neuron models

Advantages, uses, transfections

Models and examples for Neurochemistry, cultured systems as discovery tools

2. C elegans:

Advantages for Neurobiological research, transgenics, RNAi

Signaling, aging, disease models

 3. Drosophila

Advantages for Neurobiological research, transgenics, tools

Neurogenetics, sensory and cognitive models

Cognitive and neurodegenerative disease models , pharmacogenetics

4. Mouse

Advantages for Neurobiological research, transgenics

Cognitive models and methods, neuropharmacology

Neurodegenerative models and applications

Rat models, cognitive and neuropharmacology models

 

Titles of the lectures and the names of the lecturers

 

A/A

Lecture Hours

Technical courses: Methodological approaches in Neuroscience , Experimental animal models in Neuroscience

Lecturer

1

1

Tissue culture models

Spiros Efthimiopoulos

2

1

Introduction in experimental models in neuroscience

Spiros Georgopoulos

3

2

Rodents as experimental models in neuroscience

Spiros Georgopoulos

4

1

Manipulations to make transgenic mice, lab presentation

Spiros Georgopoulos

5

2

Papers Presentations (Presentations by the students of papers that involve use of experimental models in neuroscience)

Spiros Georgopoulos

6

2

Approaches to study animal behavior

Antonis Stamatakis/Irini Skaliora/Alexia Polisidis

7

2

The model of drosophila, usefulness and manipulations to make transgenic drosophila

Efthymios Skoulakis

 

2

The drosophila model for studyign neurodevelopment, learning and memory

Efthymios Skoulakis

 

2

Drosophila Models for studying cognitive and neurodegenerative diseases

Efthymios Skoulakis

 

2

C-elegans as experimental models in neuroscience

Popi Syntihaki

 

     

 

 

 

 

 

SubTotal hours of Lectures 

14