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NEUROBIOLOGICAL BASIS OF DISEASES OF THE NERVOUS SYSTEM

Co-Coordinators

Leonidas Stefanis, Professor of Neurology and Neurobiology

Spiros Efthimiopoulos, Professor of Neurobiology

Teaching hours and weekly schedule

This 2nd semester a 3,5 weeks course that corresponds to 6 ECTs and 72 total hours of teaching; 60 hours lectures and 12 hours of student presentation.

The weekly schedule could be according to the table below. The teaching hours/day may be increased if necessary

Weekly Program for 6 ECTs

6 ECTs=42 hours of teaching+30 hours student presentations

Σύνολα: 3,5 weeks Χ teaching hours/day

Monday

4

17.5

Tuesday

4

14

Wednesday

4

14

Thursday

4

14

Friday

4

14

 

 

72.5

Description

This is an intensive three and a half-week course focused on the Genetics, the general processes that operate in several different neurological disorders, the pathology of neurological disorders, their molecular basis, as well as experimental therapeutics. The goal of this intensive course is that students become well versed with the genetic and molecular basis of the disorders of the nervous system.

Course Overview

The course covers general principles that apply to several disorders of the nervous system as well as the description and the pathology and the molecular basis of individual diseases.

General principles include:

•             Protein misfolding and aggregation,

•             protein degradation

•             Inflammation

•             Neurotoxic and neurotrophic pathways

 

Examples of the diseases of the nervous system that will be covered include:

•             Alzheimer's disease

•             Parkinson's disease

•             Motor Neuron Disease

•             Schizophrenia

•             Depression

•             Triple repeat disorders

•             Epilepsy

•             Addiction

•             Nervous System Cancers

•             Brain and Spinal Cord injury

 

Skills & Learning Outcomes

Upon successful completion of this course, students will be able to:

1.            Understand the common mechanisms involved in various diseases of the nervous system

2.            Understand the genetics of neurological diseases

3.            Understand and describe the molecular pathways that operate in specific disorders of the nervous system

 

Titles of the lectures and the names of the lecturers

 

A/A

Lecture hours

Neurobiological Basis of Diseases of the Nervous System:

Lecturer

1

3

Neurodegenerative diseases as proteinopathies

Kostas Vekrellis

2

3

Genetics of Neurodegenerative diseases

John Hardy

3

3

Neurotoxic and neurotrophic mechanisms

Spiros Efthimiopoulos

4

3

Protein degradation in neurodegenerative diseases

Leonidas Stefanis-Maria Xylouri

5

3

Inflammation

Spiros Georgopoulos

6

3

Disease Biomarkers

Elisavet Kapaki

7

3

Molecular and Cellular Biology of Alzheimer's Disease

Spiros Efthimiopoulos

8

3

Molecular Basis of taupathies

Efthimios Skoulakis

9

3

Cognitive Functions and behavior in dementias

Sokratis Papageorgiou

10

3

Molecular and Cellular Biology of Parkinsons's Disease

Leonidas Stefanis

11

3

Life Style and nurodegeneration

Nikos Scarmeas

12

3

Motor Neuron Disease

Laskaro Zagoreou

13

3

Molecular and Genetic Basis of Schizophrenia

Nikos Stefanis

14

3

Biology of Depression

Christina Dalla, Nikolaos Kokras

15

3

Cognitive deficits in Schizophrenia and depression

Nikos Smyrnis

16

3

Trple repeat disorders

George Koutsis

17

3

Epilepsy

Anastasios Bonakis

18

3

Mechanisms of Addiction

Christina Dalla, Styliani Vlachou

19

3

Nervous System Cancers

Mimika Mangoura

20

3

Brain and Spinal Cord injury

Rebecca Matsa

 

 

 

 

 

Total Lecture hours

60

 

 

Total student presentation hours

12

 

 

Total teaching hours

72