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CELLULAR AND MOLECULAR NEUROSCIENCE

Co-coordinators

Dimitra Mangoura, Professor-Investigator A, Biomedical Research Foundation of the Academy of Athens, and

Zafiroula–Iro Georgoussi, Research Director, National Center for Scientific Research “Demokritos”, Athens

Teaching hours and weekly schedule

This  a 1st semester 3,5 weeks course that corresponds to 6 ECTs and 72 total hours of teaching; 42 hours lectures and 30 hours of student presentation.

The weekly schedule could be according to the table below. The teaching hours/day may be increased if necessary.

Weekly Program for 6 ECTs

6 ECTs=42 hours of teaching+30 hours student presentations

Total: 3,5 weeks Χ teaching hours/day

Monday

4

14

Tuesday

4

14

Wednesday

4

14

Thursday

4

14

Friday

4

14

 

 

70

Description

This course is designed to introduce graduate students to major processes, principles, and mechanisms associated with Cellular and Molecular Neurobiology.  Therefore the material will range from the mechanistic details of neuronal signaling and cellular function to how such properties utilized during normal brain function and neuropathology or substance abuse.  The Course involves a series of overview lectures by leading researchers in the field, a total of fifteen Instructors from Greece and across Europe, and opportunities of presenting primary research or literature review papers by students.

More specifically, this Course will include the following major topics: overview of the neuron as the fundamental unit; cell biology of neurons and glia; ion channels and electrical signaling; synaptic transmission, integration, and chemical systems of the brain; molecular properties of neurotransmitters and their receptors; and sensory systems, from transduction to perception. Students will emerge with a great awareness of how individual nerve cells function, and neurons communicate with other cells, and of the ways that neurotransmission can provide insight into basic scientific questions, all in preparation for students own contributions as neuroscientists and biologists.

Course Overview

This is a comprehensive introductory course in Molecular and Cellular Neuroscience. Basic principles of organization and function of the nervous system will be discussed and frequent reference will be made to pathophysiology of neurological and other disorders.

•             General principles of Nervous System

•             Synaptic Transmission, Neurotransmitters and their Receptors

•             Molecular Aspects of Neuronal Cells

 

Skills & Learning Outcomes

Upon successful completion of this course, students will be able to know the fundamental principles on:

  1. Neural cell biology
  2. Synapse formation and neural plasticity
  3. Intracellular trafficking and cytoskeleton-related processes
  4. Interconnections to form nerve circuits for the passage of electric signals
  5. Small molecules coupling to their cognate membrane receptors to regulate intracellular responses and biological outcomes
  6. Major intracellular signalling pathways
  7. Molecular biology of the sensory systems
  8. Energy brain metabolism

 Titles of the lectures and the names of the lecturers

 

Α/Α

Lecture Hours

Molecular and cellular neuroscience

Lecturer

 

 

Overview of the Nervous System

 

1

2

Overview of the Nervous System

Mimika Mangoura

2

2

Cell Membrane Structures and Functions; Intracellular Trafficking and  Axonal transport

Mimika Mangoura

3

2

The Cytoskeleton of  Neurons and Glia

Katia Befort

4

2

Basis of excitability, resting potential

Irini Skaliora

5

2

Passive and active properties (Action potential, cable theory)

Christos Konsoulas

6

2

Synapses (NMJ and central) signal integration and processing

Christos Konsoulas

 

2

Cellular Plasticity, LTP/LTD

Irini Skaliora/Christos Comsoulas

7

2

Astrocytes and Microglia (Neuron/glia interactions in network activity shaping

Ismini papageorgiou

 

 

Synaptic Transmission, Neurotansmitters and their Receptors

 

8

2

Synaptic Transmission,  Neurotransmitters and their receptors

Zafiroula-Iro Georgoussi

9

2

 Phosphoinositides- Cyclic Nucleotides in the Nervous System

Zafiroula-Iro Georgoussi/George Leondaritis

10

2

Neurotransmitters I:Glutamate and GABA and their  Receptors

Ada Mitsakou

11

2

Neurotransmitters II: Acetylcholine

Socrates Tzartos

12

2

Neurotransmitters III: Catecholamines

Dido Vasilakopoulou

13

2

Neurotransmitters IV: Purines, peptides and gases

Laskaro Zagoraiou

14

2

Small molecular weight G-proteins

Mimika Mangoura

15

2

 Ca2+ signaling and Homeostasis

Panagiota Papazafiri

 

2

Lipid neurotransmitters (cannabinoids)

Ismael Galve-Ropeth

 

 

Molecular Biology of Neural Cells

 

16

2

Transcription Factors in the Central Nervous System

Panagiota Papazafiri /Laskaro Zagoraiou

17

2

Protein synthesis and posttranslational modifications

Mimika Mangoura

18

2

Energy Metabolism of the Brain

Ralph Dringen

19

2

Molecular Biology of Vision and Olfaction

Mimika Mangoura

 

 

 

 

 

Total Lecture hours

42

 

 

Total student presentation hours

30

 

 

Total teaching Hour

72